Borsch Med ALL-IN-1 Glucosamine plus Collagen 10,000mg with Chondroitin & Rose Hip for Joints is a nutritional supplement specially formulated to contain 4 synergistic key ingredients, collagen peptide, glucosamine hydrochloride, chondroitin sulfate and rose hip extract to provide ALL-ROUNDED nourishment for healthy joints and cartilage.

1. COLLAGEN

Collagen is a primary connective tissue protein in the body and it forms a basic structure of skin, hair, blood vessels, cartilage and bones in the human body. Unlike native collagen, collagen peptides are highly digestible and bioavailable to the body. This highly bioavailable collagen peptide delivers essential peptide and amino acids to the body to stimulate synthesis of collagen in various parts of the body.

Types of Collagen

There are 28 types of collagen, amongst these, Type I, type II and type III collagen are the most common types of collagen in our body^[2]. These 3 types of collagen differ in their structural properties and can be found in different parts of the body.

Type I collagen is most commonly found in our skin, tendon, ligaments and bones while type II collagen is found mainly in joint cartilages.

How does type II collagen aid in joint repair and regeneration?

Chondrocytes are the only cells found in cartilages and they are made up primarily of type II collagen, proteoglycans (protein) and glycosaminoglycans (GAG). Type II collagen, proteoglycans and GAG combine to form a web-like structure which binds with water and form a pressure-resisting layer that separates the cartilage and bones. Studies have also shown that ingestion of type II collagen provides direct nutritional supplement to stimulate growth of cartilage cells.

Ｒｅｆｅｒｅｎｃｅ： http://wings.buffalo.edu/eng/mae/courses/417-517/Orthopaedic%20Biomechanics/Lecture%208a.pdf

Collagen benefits bones too!

Collagen plays an important role in the structure of bones. Collagen present in bone matrix stimulates the building of bone cells. In a study involving patients with osteoporosis, collagen together with calcitonin (a hormone in our body that regulates calcium levels) had an enhanced effect of inhibiting bone collagen breakdown, resulting in stronger and firmer bone structure. ^[3]

Daily intake of collagen is essential for repairing, regenerating worn out cartilage and strengthening bone structure for overall healthy joints!

HOW COLLAGEN IMPROVE JOINT CONDITION?

Collagen increases thickness (diameter) and density of collagen fiber in the joint cartilage.

With increased thickness and density of collagen fibers, cartilage is better able to withstand external aggressors. Collagen also has the ability to increase the water absorption and retention of moisture in cartilage. A molecule termed glycosaminoglycans (GAG) is produced by collagen. This GAG molecule is needed to be attached to proteins within body to form hyaluronic acid (HA). HA has the ability to hold large amounts of water to form a “pressure-resisting” gel. The gel formation again acts as a cushion to protect skin against external stressors. The water absorption capacity of the matrix ensures the cartilage stays hydrated, which creates a cushioning barrier in the joints that reduces the incidences of bones grinding togdether when joints are moved.This will greatly improve joint flexibility and reduces pain.

2. GLUCOSAMINE HYDROCHLORIDE

Glucosamine supports the building and maintenance of cartilage cells and helps to repair every day wear and tear of joints. Glucosamine plays a key role in the regeneration of cartilage cells by stimulating the production of glycosaminoglycans (GAG). GAG combines with proteoglycans and type II collagen to form a network which holds water and increase in mass which acts as a cushion between joints. This cushioning effect of the network reduces the friction resulted from the daily movement of joints hence reducing the incidences of swollen, inflamed joints and joint pain.

Intake of glucosamine has a direct effect in slowing down the progression of osteoarthritis^[5]!

3. CHONDROITIN SULFATE

Chondroitin sulfate is naturally present in our body but its level decreases as we age. Effective replenishment through diets or supplements provide lubrication to joints to promote mobility and flexibility.

Proteoglycans is one of the most common and largest matrix molecules present in cartilage cells apart from type II collagen. Proteoglycans contains a lot of chondroitin sulfate molecules which interacts with hyaluronic acids to form a matrix.

This matrix binds large amounts of water. This large water holding capacity forms a fibrillar network which swells to create a pressure that resists deformation of the cartilage which acts as a cushion between joints for enhanced joint mobility and flexibility.^[6]

The water holding capacity of the matrix also allows for enhanced delivery of nutrients (dissolved in water) to the cartilage area to promote joint repair and regeneration.

Figure: Illustration showing how chondroitin forms a fibrillar network with hyaluronic acid to bind water for cushioning effect in joints cartilage 

Ｒｅｆｅｒｅｎｃｅ：http://www.marvistavet.com/normal-joint-structure.pml

4. ROSE HIP EXTRACT

Rose hip extract is an active ingredient which contains high levels of antioxidants which relieves joint inflammation and alleviates joint pain.

How does rose hips reduces joint inflammation and joint pain?

Inflammation in joints is caused by 2 factors, wear and tear of joints due to cartilage being eroded from overuse of joints (osteoarthritis) as well as inflammation caused by body’s immune cells attacking the cartilage (rheumatoid arthritis).

Inflammation at normal levels triggers healing process. If inflammation goes out of control, such as in rheumatoid arthritis, it could affect daily life. Over activity of the immune system caused by stress and improper diet, triggers body to produce cartilage degrading enzymes, which degrades the joint cartilage resulting in rheumatoid arthritis.

Rose hip extract was shown to reduce cartilage degrading enzymes^[7] which reduces incidence of body’s immune system from breaking down the joint cartilage, effectively relieving joint inflammation and pain. 

Rose hip also contains antioxidants such as polyphenols, anthocyanins and vitamin C which have anti-inflammatory properties to relieve joint pain and discomfort.

Ｒｅｆｅｒｅｎｃｅｓ

[1] http://www.who.int/chp/topics/rheumatic/en/

[2] Collagen: The Fibrous Proteins of the Matrix. National Center for Biotechnology Information National Institute of Health
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mcb&part=A6542

[3] Moskowitz, R. 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in arthritis and rheumatism, 30 (2): 87-99.

[4] https://examine.com/supplements/type-ii-collagen/

[5] (1998). Alternative Medicine Review, Volume (3), Number1, pp34.

[6] A R Poole,et al, Type II collagen degradation and its regulation in articular cartilage in osteoarthritis, Annals of Rheumatic Diseases (2002; 61 (Suppl II): pg78-81)

[7] https://examine.com/supplements/rose-hip/

[8] Wu,J., Fujioka, M., Sugimoto, K., Mu, G. and Ishimi, Y. 2004. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats, Journal of bone and mineral metabolism, 22: 547-553

[9] Guillerminet, F., et al. 2010. Collagen Peptides improves bone metabolism and biochemical parameters in ovarictomized mice: an in vitro and in vivo study. Bone.

Are you suffering from painful and swollen joints?

Do you find that your movements are limited due to joint numbness?

These symptoms are a result of Osteoarthritis, a joint disease caused by degradation of joint cartilage.

Chronic degeneration of the joints (osteoarthritis) has been considered as one of the most disabling diseases in developed countries. Among those affected, 80% of them have limitations in movement and 25% encounter problems when performing daily activities ^[1].

Osteoarthritis is the most common type of joint problem in:

• Men & Women above 45 years old
• Athletes
• Overweight individuals

It is a degenerative disease that worsens over time.

It affects knees, hips, hands, spine or shoulders, may become severe enough to make daily tasks difficult and also, lead to higher chance of getting fractures.

COMMON SYMPTOMS OF OSTEOARTHRITIS

• Stiff and painful joints? 
• Loss of flexibility and reduced mobility in joints 
• Swelling and tender joints 
• Creaky or grinding sensation in joints
• Pain during sports/ exercise 

WHAT HAPPENS TO OUR JOINTS AS WE AGE?

As we age, our cartilage starts to deteriorate from wear and tear; bones begin to rub against each other and erode. As the cushioning cartilage begins to break down, joints become inflamed and arthritic, resulting in pain when joints are moved.

WHAT CAUSES JOINT ISSUES?

Excess weight

Excess body weight exerts extra stress on our joints, especially the knees. Over the years, our knees carried and withstood the weight from our bodies. When we age, our knees are the first to show signs of discomfort due to eroded cartilage.

Excessive exercise

Exercise causes joint to experience more severe wear and tear. This often results in overworked joints if no proper nutrition is supplemented. This could result in injuries to joint cartilages which increased the risk of osteoarthritis.

Stress and irregular diets

Stress and irregular diets are a norm for individuals leading a busy lifestyle. Our diets consisted mainly of processed foods which are stripped of many essential nutrients. Our regular diets no longer provide enough nutrients such as collagen, glucosamine and chondroitin for maintenance of healthy joints.

Overtime, due to the lack of nutritional support adding on to overworked joints, cartilage starts to erode and breakdown, resulting in inflammation and pain.

Ｒｅｆｅｒｅｎｃｅｓ

[1] http://www.who.int/chp/topics/rheumatic/en/

[2] Collagen: The Fibrous Proteins of the Matrix. National Center for Biotechnology Information National Institute of Health
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mcb&part=A6542

[3] Moskowitz, R. 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in arthritis and rheumatism, 30 (2): 87-99.

[4] https://examine.com/supplements/type-ii-collagen/

[5] (1998). Alternative Medicine Review, Volume (3), Number1, pp34.

[6] A R Poole,et al, Type II collagen degradation and its regulation in articular cartilage in osteoarthritis, Annals of Rheumatic Diseases (2002; 61 (Suppl II): pg78-81)

[7] https://examine.com/supplements/rose-hip/

[8] Wu,J., Fujioka, M., Sugimoto, K., Mu, G. and Ishimi, Y. 2004. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats, Journal of bone and mineral metabolism, 22: 547-553

[9] Guillerminet, F., et al. 2010. Collagen Peptides improves bone metabolism and biochemical parameters in ovarictomized mice: an in vitro and in vivo study. Bone.

Clinical Study 1

An enhanced healing effect for joint cartilage injury is observed when Collagen is consumed together with glucosamine!

Figure 1. Macroscopic image of cartilage 2 weeks after operation.

Ｒｅｆｅｒｅｎｃｅ： Masaki Hashida, et al., 2003, Synergistic effects of D-glucosamine and collagen peptides on healing experimental cartilage injury. Macromolecular Biochem (Vol 3; issue 10; pp596-603)

Clinical Study 2

Consumption of Collagen increased cartilage content of osteoarthritic patients, resulting in stronger joints!

Figure 2. Study showed consumption of collagen significantly increased the cartilage content of osteoarthritic patients after 24 weeks of treatment (indicated by the change from reddish yellow to green).

Ｒｅｆｅｒｅｎｃｅ：T.E. MaAlindon, et al., (2011), Change in knee osteoarthritis cartilage detected by delayed gonalinium enhanced MRI followed treatment with collagen hydrolysate: a pilot randomized controlled trial. Osteoarthritis and Cartilage (19:399-405)

Clinical Study 3

Joint pain reduced significantly for osteoarthritic patients who consumed Collagen!

Figure 3. Osteoarthritic pain experienced by patients who consumed collagen is significantly lower than patients who consumed glucosamine.

Ｒｅｆｅｒｅｎｃｅ：Tomas Trc, et al., 2011, Efficacy and Tolerance of Enzymatic Hydrolyzed Collagen (EHC) vs. Glucosamine sulfate (FS) in the treatment of Knee Osteoarthritis (KOA). Int Orthopaedics (35:341-348)

Reviews from Customers

• Add 1 sachet into 200ml of water or any beverage of your choice.
• Stir until powder completely dissolves.

• Consumers with medical conditions, pregnant woman and children should consult a physician or medical professional before use.

Q1. At what age should I start taking Borsch Med ALL-IN-1 Glucosamine plus Collagen 10,000mg with Chondroitin & Rose Hip for Joints?

Q2. How to take for best results?

Q3. How long does it take to see the effects?

Q4. How is Borsch Med ALL-IN-1 Powder for Joints different from other joint supplements?

Q5. Are there any side-effects associated with long term consumption?

Q6. Does Borsch Med ALL-IN-1 Powder for Joints contain steroids for pain management?

Q7. Will long term consumption of Borsch Med ALL-IN-1 Powder for Joints lead to weight gain?

Q8. If I have already been consuming glucosamine supplement, can I still take Borsch Med All in 1 Collagen for joints?

Q9. If doctor has prescribed me a joint supplement that contains collagen and glucosamine (same as All in 1). Can I still take Borsch Med All in 1?

Q10. What is the best time to consume this product?

Q11. What is the water temperature that could be used to dissolve the powder?

Q12. What beverage is recommended to consume this product with?

Q13. I have diabetes. Can I take this product?

Q14. I have kidney or heart problem. Can I take this product?

Q15. Which ingredient helps to regenerate cartilage.

Q16. If I am taking other supplements (not joint supplements), can I consume together?

Q17. If I am taking Chinese Medicine, Can I consume together?

Q18. Does this product absorb well? How do I know if this product is well-absorbed by my body?

Q19. Why does the powder not dissolve? How to facilitate the dissolving of powder?

Q20. One tin can last for how long?

Q21. Where is this product manufactured from? Where are all the ingredients from? If it is from Japan, is it safe for consumption?

Q22. Can pregnant women, children or consumers with existing medical conditions consume Borsch Med All in 1 Collagen for Joints?

Q1. At what age should I start taking Borsch Med ALL-IN-1 Glucosamine plus Collagen 10,000mg with Chondroitin & Rose Hip for Joints?

A1. You should start taking it as early as in your early 20s for people leading an active lifestyle. Conditions of osteoarthritis worsen with age due to everyday wear and tear of joints. Borsch Med ALL-IN-1 Powder for Joints helps to renew and reduces degeneration of joint cartilage and relieves joint discomfort.

Q2. How to take for best results?

A2. It is recommended to take 2 scoops daily for best results. You may mix it with your favourite beverages.

Q3. How long does it take to see the effects?

A3. Results may vary with individuals. Some experience improvement in joint discomfort within 2 – 4 weeks. However, it is advisable to consume the products continuously for a period of at least 3 months for observable and sustainable results.

Q4. How is Borsch Med ALL-IN-1 Powder for Joints different from other joint supplements?

A4. Borsch Med ALL-IN-1 Powder for Joints is specially formulated with 10,000mg collagen (daily intake requirement for joint health), glucosamine, chondroitin and rose hip extracts, in which each ingredient serves a specific function yet working synergistically together to ensure optimal benefits towards joint health.

Q5. Are there any side-effects associated with long term consumption?

A5. Borsch Med ALL-IN-1 Powder for Joints have no known side effects and is safe for long term consumption.

Q6. Does Borsch Med ALL-IN-1 Powder for Joints contain steroids for pain management?

A6. No. Borsch Med ALL-IN-1 Powder for Joints uses all natural ingredients that are free from steroids. You will experience benefits of pain relief from rose hip extract which serves anti-inflammatory properties to relieve swelling and pain.

Q7. Will long term consumption of Borsch Med ALL-IN-1 Powder for Joints lead to weight gain?

A7. Borsch Med ALL-IN-1 Powder for Joints does not contain any fats and sugar. Hence long term consumption will not result in weight gain

Q8. If I have already been consuming glucosamine supplement, can I still take Borsch Med All in 1 Collagen for joints?

A8. Research has shown that consuming glucosamine alone is not as effective in treating joint ailments than consuming collagen AND glucosamine. Collagen and glucosamine consumed together could speed up joint regeneration and healing process. You could switch entirely to Borsch Med All in 1 that has all the nutrients needed for optimal joint health.

Q9. If doctor has prescribed me a joint supplement that contains collagen and glucosamine (same as All in 1). Can I still take Borsch Med All in 1?

A9. It is recommended to check the dosage of collagen and glucosamine in each daily intake. If the collagen content is below 10,000mg and glucosamine content is below 1,500mg, you could consume Borsch Med All in 1 Collagen for Joints because Borsch Med All in 1 Collagen for Joints contains all the essential ingredients to regenerate cartilage, improve joint mobility and flexibility and provides relief from pain and inflammation.

Q10. What is the best time to consume this product?

A10. This product can be consumed any time of the day, however, it is preferred to be consumed after meals for better absorption.

Q11. What is the water temperature that could be used to dissolve the powder?

A11. It is best to dissolve in luke-warm or room temperature water. Avoid adding to hot, boiling beverages.

Q12. What beverage is recommended to consume this product with?

A12. You could consume this product with any beverages except coffee and tea. But it is recommended to consume together with milk, because the calcium from the milk together with collagen will increase density of bones to build strong bones. (Majority of the bones is made up of collagen)

Q13. I have diabetes. Can I take this product?

A13. Not recommended. Glucosamine is a type of sugar and may raise blood sugar levels.

Q14. I have kidney or heart problem. Can I take this product?

A14. Not recommended. Collagen is a micro-protein and consuming this product might increase the burden to kidneys and heart.

Q15. Which ingredient helps to regenerate cartilage.

A15. Collagen is the main ingredient used to regenerate cartilage. But research findings showed that consuming collagen AND glucosamine has enhanced the regeneration rate of the cartilage cells than consuming collagen or glucosamine alone.

Q16. If I am taking other supplements (not joint supplements), can I consume together?

A16. Borsch Med All in 1 Collagen for Joints contain all natural ingredients and will not have any interactions if consumed together with other supplements. However, for best efficacy, we recommend to consume Borsch Med All in 1 2 hours before or after consuming other supplements.

Q17. If I am taking Chinese Medicine, Can I consume together?

Q17. It is best to separate the consumption of Borsch Med All in 1 from the Chinese Medicine by 2 hours for best efficacy.

Q18. Does this product absorb well? How do I know if this product is well-absorbed by my body?

A18. The molecular weight of the ingredients are very small. This facilitates absorption in the body. Typical adults observed improvement to their joints 2 to 3 weeks after consuming this product.

Q19. Why does the powder not dissolve? How to facilitate the dissolving of powder?

A19. The ingredients are in small molecular weight, therefore the powder particles are very small. Small particles has higher surface tension, hence it is harder to dissolve. To facilitate the dissolution of powder, it is best to mix in lukewarm water.

Q20. One tin can last for how long?

A20. Typically 26 days, if you consume the daily suggested intake indicated on the packaging.

Q21. Where is this product manufactured from? Where are all the ingredients from? If it is from Japan, is it safe for consumption?

A21. This product is manufactured from Japan (Osaka). All the ingredients are from Japan. Since the product is from Japan, the manufacturing plant has been certified to be free from radiation (manufactured in a radiation free premise).

Q22. Can pregnant women, children or consumers with existing medical conditions consume Borsch Med All in 1 Collagen for Joints?

A22. It is recommended for pregnant women, children or consumers with existing medical condition to consult a physician before consuming this product.